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PHLPP Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marke: Proteintech 22789-1-AP-20UL
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Beschreibung
PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.Spezifikation
| PHLPP | |
| Polyclonal | |
| Unconjugated | |
| PHLPP1 | |
| hSCOP, KIAA0606, PHLPP, PHLPP1, PLEKHE1, SCOP | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 23239, 98432 | |
| -20°C | |
| Liquid |
| Immunocytochemistry, Immunoprecipitation, Western Blot, Immunofluorescence, Immunohistochemistry (Paraffin) | |
| 0.57 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| O60346, Q8CHE4 | |
| Phlpp1 | |
| PHLPP Fusion Protein Ag18794 | |
| 20 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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